L-Selectin anticorps

N° du produit ABIN452283

Cet anticorps anti-L-Selectin est un anticorps Souris Monoclonal détectant L-Selectin dans FACS, WB, IP, Func et IHC (fro). Adapté pour Humain.

Aperçu rapide pour L-Selectin anticorps (ABIN452283)

Antigène: L-Selectin (SELL) (Selectin L (SELL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp L-Selectin est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: DREG56

Détail du produit anti-L-Selectin anticorps

Specificité: This antibody recognizes CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1, Lymph node homing receptor,Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelialcell adhesion molecule 1, CD62 antigen-like family member L

Purification: Protein A Affinity Chromatography

Immunogène: PMA-activated human peripheral blood leukocytes

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 2 μg/mL. Immunoprecipitation. Western blot (non-reducing conditions). Immunohistochemistry on frozen sections. Functional application: Particularly effective in blocking of lymphocyte CD62L-mediatedbinding to peripheral lymph node HEV.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur L-Selectin

Antigène: L-Selectin (SELL) (Selectin L (SELL))

Autre désignation: CD62L / L-Selectin

Classe de substances: Chemical

Sujet: CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.Synonyms: CD62 antigen-like family member L, LAM-1, LECAM1, LNHR, LYAM1, Leu-8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, SELL, TQ1, gp90-MEL

ID gène: 6402

UniProt: P14151